World Journal of
Pharmaceutical and Life Sciences

A STUDY ON DRUG-DRUG INTERACTIONS DUE TO POLYPHARMACY IN TERITARY CARE HOSPITAL IN SOUTHERN INDIA

Lakshmi Meghana Potluri*, Mohana Mudhitha Vadlapatla, Jyothirmayee Kongara, Dhanush Bellapu,
Padmalatha Kantamneni

ABSTRACT

The study was conducted to monitor the clinically significant complexity occur due to the use of multiple drug therapy which may further lead to drug drug interactions (DDI’S). Drug interaction generally refers to a modification of the expected drug response in the patient as a result of exposure of the patient to another drug or substance. DDIs became the commonest problem globally the overall DDIs which had occurred has been reported and recorded. The clinical outcomes may increase the risk of drug toxicity or increase adverse drug report (ADR). DDIs are divided into three groups depending on the underlying mechanism of interaction: pharmaceutical, pharmacokinetic, pharmacodynamic interactions. Polypharmacy is considered as one of the major risk factors in precipitation of DDIs. Patient population at high risk include the elderly and patients with co-morbidities as they are usually prescribed with more number of drugs. Critical evaluation of such prescriptions by pharmacist could result in identification and reduction of such problems.

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