World Journal of
Pharmaceutical and Life Sciences

CHURG–STRAUSS SYNDROME: A REVIEW

*Prof. Savitha Mol G. M., Silvia Navis A. and Prasobh G. R.

ABSTRACT

Churg–Strauss syndrome (CSS) is a rare diffusive granulomatous necrotizing small vessel vasculitis characterized by the presence of asthma, sinusitis, and hypereosinophilia. The cause of this allergic angiitis and granulomatosis is unknown. Other common manifestations are pulmonary infiltrates, skin, gastrointestinal, and cardiovascular involvement. No data have been reported regarding the role of immune complexes or cell mediated mechanisms in this disease, although autoimmunity is evident with the presence hypergammaglobulinemia, increased levels of IgE and Antineutrophil cytoplasmic antibody (positive in 40%). Th2 response is of special importance in the up regulation of different interleukins such as IL-4, IL-13, and IL-5. Th1 and Th17 responses are also of significance. Activated eosinophils have a prolonged survival and probably cause tissue damage by releasing eosinophil granule proteins, while their tissue recruitment can be regulated by chemokines such as eotaxin-3 and CCL17. The aim of this review is to find out the possibility of new therapeutic approaches to Churg- Strauss Syndrome.

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