World Journal of
Pharmaceutical and Life Sciences

REVIEW ON LIQUISOLID COMPACT TECHNIQUE

Tanzeel Majeed*, Mohd. Iqbal Bhat, Ganesh N. S. and Vineeth Chandy

ABSTRACT

Dissolution of a drug and its release from the dosage form has basic impact on bioavailability. The active amount of the drug present at the target site depends upon solubility. The major challenge that the pharmaceutical industry is facing is the Solubility of the drug with the development of new pharmaceutical products.[1] There solubility can be enhanced by various approaches which includes micronization, Nanonisation, use of salt forms, use of surfactant, solid dispersion, and supercritical fluid recrystallization etc. Liquisolid technique is a latest and promising approach towards such novel drug delivery system, that the solubility of the insoluble drug moiety is enhanced by the using non-volatile solvents and hence improves the dissolution and bioavailability.[2] The experiment involves dissolving the insoluble drug into a non-volatile solvent and the mixture of a drug loaded solutions with appropriate carrier and coating materials are added to convert it into acceptably flowing and compressible powders.[3] The pharmaceutical medications such as solutions or suspensions which are water insoluble drugs in a suitable non-volatile liquid vehicles can be easily converted into powder form with acceptable flow properties and compression behaviour using suitable powder excipients.[4] The use of non-volatile solvent leads to improved wettability, improved solubility and ensures molecular dispersion of drug in the formulation. By using non-volatile solvents the release of the drugs can be modified by this technique, also solubility and dissolution rate can be improved, sustained drug delivery systems can be developed for the water soluble drugs.[5]

[Full Text Article]