World Journal of
Pharmaceutical and Life Sciences

STANDARDIZATION OF THE DURVADI LEPA

Dr. Ravindra B. Atram*, Dr. Smita S. Kolte, Dr. Shrawan N. Kamble, Dr. Jayshree N. Kolhe and Dr. Yogesh L. Manani

ABSTRACT

Durvadi Lepa which contains Durva, Chakramarda, Tulasi, Haritaki and Saindhav lavana has described in Chakradatta in the management of Kushtha. In this formulation mostly drugs have Kushtaghna and Chakramarda is also mentioned as a ringworm plant having Dadrughna (antifungal) action. Here to Treat Dadru (Ringworm) local application of Durvadi Lepa is selected. The present work was carried out to standardize the finished product Durvadi Lepa to conform its identity, quality and purity. The pharmacognostical work of Mixture of Durvadi Lepa reveals that presence of fragments of border pitted vessels annular and spiral vessels; fibres, simple and compound starch grains, Prismatic crystals, Silica deposits, A normocytic stomata, seriated unicellular trichomes, Rosette crystals of calcium oxalate, epidermal cells with stomata, parenchyma cell with starch grain, fibres, xylem & phloem, oil globules, Mesocarp cells, Simple pitted vessels and Scalariform vessels had observed microscopically from Mixture of Durvadi Lepa. Organoleptic features of Durvadi Lepa made out of the crude drugs were within the standard range as mentioned in the classic. Foreign matter was NIL, Loss on drying (110?c) was 5.45%w/w, Total Ash Value was 32.22 % w/w, Acid insoluble Ash value was 3.88%w/w, and Methanol soluble extraction was 8.35 % w/w and water soluble extraction was 45.51% w/w.

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