Abstract
THE EFFECT OF ALOE VERA POWDER (Aloe vera (L.) Webb) ON PHYSICAL PROPERTIES OF MUCOADHESIVE MICROGRANULES CONTAINING RANITIDINE HYDROCHLORIDE
Endang Diyah Ikasari*, Anang Budi Utomo, Hanny Setyowati, Salasa Ayu Trisnawati
ABSTRACT
Ranitidine hydrochloride is a competitive inhibitor of histamine H2-receptors, drug of choice in the treatment of ulcer. The drug has a short biological half life of approximately 2–3 hours, thus a sustained release dosage form of ranitidine HCl is desirable. The aim of this study was to formulate and in vitro evaluate microgranules with ranitidine HCl. Microgranules were prepared by the wet granulation method using aloe vera powder as bioadhesive polymer. Increasing concentration of aloe vera powder results decreasing of flow rate, improving of moisture content, swelling index, in vitro bioadhesive, and dissolution efficiency. The obtained results indicated that aloe vera powder is a suitable polymer for developing a sustained-release dosage form of ranitidine HCl for local delivery in the gastro intestinal tract.
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