World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), Web of Science Group (Under Process), Directory of Research Journals Indexing, Scholar Article Journal Index (SAJI), International Scientific Indexing ( ISI ), Scope Database, 

Abstract

THE EFFECT OF ALOE VERA POWDER (Aloe vera (L.) Webb) ON PHYSICAL PROPERTIES OF MUCOADHESIVE MICROGRANULES CONTAINING RANITIDINE HYDROCHLORIDE

Endang Diyah Ikasari*, Anang Budi Utomo, Hanny Setyowati, Salasa Ayu Trisnawati

ABSTRACT

Ranitidine hydrochloride is a competitive inhibitor of histamine H2-receptors, drug of choice in the treatment of ulcer. The drug has a short biological half life of approximately 2–3 hours, thus a sustained release dosage form of ranitidine HCl is desirable. The aim of this study was to formulate and in vitro evaluate microgranules with ranitidine HCl. Microgranules were prepared by the wet granulation method using aloe vera powder as bioadhesive polymer. Increasing concentration of aloe vera powder results decreasing of flow rate, improving of moisture content, swelling index, in vitro bioadhesive, and dissolution efficiency. The obtained results indicated that aloe vera powder is a suitable polymer for developing a sustained-release dosage form of ranitidine HCl for local delivery in the gastro intestinal tract.

[Full Text Article]

BEST PAPER AWARDS

World Journal of Pharmaceutical and life sciences Will give best paper award in every issue in the from of money along with certificate to promote research .

Best Article of current issue

Download Article : Click here