World Journal of
Pharmaceutical and Life Sciences

ASSESSMENT OF FIXED DOSE COMBINATIONS IN CARDIOVASCULAR DISEASES

Mohammad Rehana Begum*

ABSTRACT

Aim: The study aims at assessing fixed dose combinations in cardiovascular diseases. Background: Cardiovascular disease (CVD) includes hypertension, myocardial infarction, atherosclerosis, coronary artery disease and congestive heart failure. Fixed dose combinations (FDC) are the drugs with more than one drug in fixed ratio with valid therapeutic principles. Methodology: A number of effective therapies reduce the risk of morbidity and mortality in patients with a retrospective study conducted in a tertiary care hospital at Hyderabad for 8 months from November 2017 to June 2018. During this period a total of 150 prescriptions were collected and analysed. Results: The study is comprised of 57% males and 43% females with more than 50% of patients being obese. 2110 FDCs are prescribed and all of them were Branded products. The total No. of FDCs prescribed were 69.95% and 30.04% were of Repeated FDCs Drugs. The number of combinations were 56.66% of FDCs were Two drugs combination, 42% of FDCs were Three drugs combination, 1.34% of FDCs were More than three drugs. The margin of error of repetitive drugs is in between 0.53%-1.70%. 23% of cases were the highest comorbid percentage assessed for Hypertensive patients. 24% of cases are having a social background of consuming both alcohol and smokers. The highest number of FDCs prescribed were Antihyperlipidemic and Antiplatelet.

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