World Journal of
Pharmaceutical and Life Sciences

OXIDATIVE STRESS FOLLOWING INTOXICATION OF COPPER SULPHATE AND POTASSIUM DICHROMATE IN ALBINO RATS

Pushpendra Tiwari, Prabhu Narain Saxena and Brijender Bhushan*

ABSTRACT

Trace heavy metals are integral components of body cells and responsible for various metabolic reactions. In addition, they are also a part of broad variety of consumer products. Any alteration in their level with in the body of an organism can prove fatal. It is thus very important to use and release them within appropriate limits. Present study deals with the toxicity assessment in terms of oxidative damage, of two broadly used trace heavy metals, copper and chromium. Albino rats have been selected as experimental animals in this study. Adenosine triphosphatase (ATPase), lipid peroxidase (LPO), Glutathione-s-transferase (GST) and metallothioneins have been selected as parameters to assess the oxidative damage. ATPase has been found to decrease biochemically within the liver and serum of intoxicated rats, where as other selected parameters showed an increasing pattern. This may be a consequence of the oxidative stress caused by these two trace heavy metals respectively. These biochemically analyzed numerical values were positively correlated together.

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