World Journal of
Pharmaceutical and Life Sciences

SURVIVAL OUTCOME COMPARISON BETWEEN EARLY AND LATE OXYGEN THERAPY AMONG PRETERM NEONATES SUFFERING FROM RESPIRATORY DISTRESS SYNDROME IN IBN AL-BALADI HOSPITAL / BAGHDAD- IRAQ

Dr. Talib Hasan Darhash Al-Tamimi*, Dr. Kaddum Kudair Abbas AL-Taie and Dr. Jenan Ghadban Dawood

ABSTRACT

Prematurity and RDS largely contribute to early neonatal morbidity and mortality. With adequate antenatal steroid and early CPAP, early oxygen therapy improves survival outcome. The current study aimed to compare survival outcome of oxygen therapy with respect to timing of its administration (i.e. early within two hours of life and late after 2 hours), different birth weight and different gestational age. This prospective interventional study included newborns with 24-28 weeks prematurity or 28-34 weeks (GA) with clinical RDS and birth weight (BW)>650gms. All subjects were preferably provided early oxygen therapy (within 2 hours after birth). Oxygen was delivered and only those who required further respiratory support were ventilated. Records on birth weight, gestational age, and timing of therapy (early/late), duration of ventilation, sepsis, complications, and survival/death outcome were collected and data was analyzed using SPSS version 20. Out of 80 neonates (39 males, 41 female), 36 received early oxygen therapy and 44 obtained it late. Although high mortality was observed with both early (32.8%) and late therapy (67.2%), there was significantly higher survival with early therapy (p=0.02). Though no statistical differences of outcome were observed with different GA and BW in study groups; however irrespective of timing of therapy, higher mortality occurred in lower BW/GA subgroups with least survival among extremely preterm <27wks (p=0.005) and ELBW<1000gm (p=0.001). No difference was seen for need of intubation/ventilation in early and late groups (p=0.831). It can be concluded that early oxygen administration improved survival with minimal complications in RDS except for extremely premature/LBW babies.

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