World Journal of
Pharmaceutical and Life Sciences

EFFICACY AND SIDE EFFECTS OF SILDENAFIL CITRATE IN PATIENTS ON CHRONIC HAEMODIALYSIS WITH ERECTILE DYSFUNCTION

Muhammad Shahbaz Ali*, Safdar Shah, Zeshan Ali, Muhammad Ayub, Wajid Ali, Imran Ansari

ABSTRACT

Introduction: Medical Erectile dysfunction is the inability to achieve or maintain an erection for a satisfactory sexual performance. Objective: The objective of this study was to find the efficacy and frequency of side effects of sildenafil citrate in patients on chronic hemodialysis with erectile dysfunction (E.D). Methods: This study was involved 165 patients of renal failure on hemodialysis for at least six months presenting with erectile dysfunction. Sildenafil citrate (50 mg) tablet were converted into powder form and filled it in capsules. All patients received a sealed box containing the capsules. one capsule containing sildenafil citrate (50 mg) was given to all patients twice a week and advised them to take these capsules one hour before the intercourse and continue this treatment for two weeks. Results: Erectile dysfunction improved in 145 (87.9%) patients. There was no significant difference in the frequency of efficacy across age (p=0.496), duration of renal failure (p=0.901) and baseline IIEF (p=0.543) groups. Headache was the most frequent side effect and was reported by 27 (16.4%) patients followed by flushing (n=21, 12.7%), blurring of vision (n=9, 5.5%) and dyspepsia (n=7, 4.2%). Conclusion: The efficacy of sildenafil citrate was found to be 87.9% in patients of renal failure on hemodialysis presenting with erectile dysfunction. This efficacy was unaffected by patients’ age, duration of renal failure and baseline IIEF score.

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