World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

THE ACUTE TOXICITY OF THE AQUEOUS EXTRACT OF ARISTOLOCHIA LONGA L, « MOROCCO » PREPARED BY THE TRADITIONAL METHOD

Fatima Zahra Benaddi*, Abdelilah Ouahbi, Meryem Bellahmar and Said Chakir

ABSTRACT

Medicinal plants are one of the main resources of therapeutic agents. Among Moroccan medicinal plants, Aristolochia longa, it is a species commonly used in Moroccan traditional medicine. The present study was conducted to investigate the effect of the aqueous extract of aristolochia longa in albinos mice. Acute toxicity test was performed to determine lethal 50, lethal dose 100 and minimum lethal dose. The administration of the aqueous extract induced the appearance of several symptoms of toxicity like Weakness, convulsion, diarrhé, hypoactivity. Our results show that the highest dose killing all animals or lethal dose 100 is 12 g / kg, maximum tolerated dose is 5 g / kg and the lethal dose 50 is 7.6 ±1.33 g/kg. Our study suggest non toxicity of the aristolochia longa aqueous extact.

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