World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), Web of Science Group (Under Process), Directory of Research Journals Indexing, 

Abstract

THE ACUTE TOXICITY OF THE AQUEOUS EXTRACT OF ARISTOLOCHIA LONGA L, « MOROCCO » PREPARED BY THE TRADITIONAL METHOD

Fatima Zahra Benaddi*, Abdelilah Ouahbi, Meryem Bellahmar and Said Chakir

ABSTRACT

Medicinal plants are one of the main resources of therapeutic agents. Among Moroccan medicinal plants, Aristolochia longa, it is a species commonly used in Moroccan traditional medicine. The present study was conducted to investigate the effect of the aqueous extract of aristolochia longa in albinos mice. Acute toxicity test was performed to determine lethal 50, lethal dose 100 and minimum lethal dose. The administration of the aqueous extract induced the appearance of several symptoms of toxicity like Weakness, convulsion, diarrhé, hypoactivity. Our results show that the highest dose killing all animals or lethal dose 100 is 12 g / kg, maximum tolerated dose is 5 g / kg and the lethal dose 50 is 7.6 ±1.33 g/kg. Our study suggest non toxicity of the aristolochia longa aqueous extact.

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