World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

EVALUATION FOR THE FIRST TIME OF THE ACUTE DIURETIC ACTIVITY OF RUTA CHALEPENSIS L AQUEOUS EXTRACT AERIAL PART FROM MOROCCO IN WISTAR RATS

Bellahmar Meryem*, Ouahbi Abdelilah, Benaddi Fatimazahra and Boutahricht Mohammed

ABSTRACT

Medicinal plants have proven their important activity among time history in different diseases treatment and helping the production of novel drugs. Ruta chalepensis L. (family: Rutaceae), commonly named Awermi and Fijel in Morocco. It is used, in the traditional medicine for the treatment of various disorders, as analgesic and antipyretic and for the treatment of rheumatism and mental disorders. Also it has emmenagogue, abortificient, antihelmintic and spasmolytic effects as well as its potency as anti-inflammatory, antihelminthic, antifungal, antifertility, anticonvulsant and sedative. In children, infused Ruta chalepensis L leave extract has been used for treatment of convulsion and other nervous disorders. In Africa, the aqueous decoction of the leaves is used for the treatment of fever. The purpose of this study was to examine the acute diuretic potential and effect on urinary electrolytes of the aqueous extract aerial parts of Ruta chalepensis L at a dose of 3.5g/kg, 4.5g/kg and 10g/kg in normal wistar male and female rats. The aqueous extract was administered intraperitoneally and the diuresis was followed in the first hour, second hour, fourth hour and 24 h. The administration of the aqueous Ruta chalepensis L extract produced a significant increment on diuresis from the first hour to the 24 hour. Furosemide at a dose of 20 mg/kg, adminestred intraperitoneally had a similar effect when compared to Ruta Chalepensis L administration suggesting a similar mechanism of action. The mechanism of action of furosemide is by inducing a loss of water through the inhibition of NaCl reabsorption. The results suggest that this receptor-mediated mechanism may account for the diuretic effect of Ruta chalepensis L as well. We concluded that aqueous extract aerial parts of Ruta Chalepensis L administered, particularly, at the dose of 10 g/kg induce significant effect on urinary output of water and electrolytes in normal wistar rats.

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