World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

SIMULTANEOUS ESTIMATION OF METFORMIN AND GLIMIPRIDE IN PURE AND TABLET FORM BY RP-HPLC METHOD

Prapulla Putta*

ABSTRACT

A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Metformin and Glimepride, in its pure form as well as in tablet dosage form. Chromatography was carried out on a Hypersil C18 (4.6 x 150 mm, 5?m) column using a mixture of Acetonitrile: TEA Buffer pH 4.2 (75:25) as the mobile phase at a flow rate of 1.0 ml/min, the detection was carried out at 259 nm. The retention time of the Metformin and Glimepride was 2.344, 3.282 ±0.02 min respectively. The method produce linear responses in the concentration range of 100-500mg/ml of Metformin and 0.4-2 mg/ml of Glimepride. The method precision for the determination of assay was below 2.0% RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.

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