World Journal of
Pharmaceutical and Life Sciences

THE INTERACTION OF MECILLINAM AND FOSFOMYCIN INTO MULTI DRUG RESISTANT ESCHERICHIA COLI FROM URINE PATIENTS

Faisal Mohammed Basher Al-Sarraj* Ahmed Mahmoud Al-Hejin Asif A. Jiman- Fatani

ABSTRACT

Urinary Tract Infection is one of the most common diseases that is very difficult to cure because of the presence of multi-Drug resistant pathogens. The cure is usually to prescribed antibiotics, however, there is a gap in terms of the type of antibiotic that was being prescribed, the amount of the dosage and the duration of the antibiotic treatment, which caused the development of multidrug resistant pathogens. The scope of this study is to look for an alternative method of curing the infection specifically caused by the Escherichia Coli bacteria. Two antimicrobials considered in this study namely, Fosfomycin and Mecillinam. There are six methods that were used in this study namely; Urothelial cell line culture, Bacterial Culture, Determination of Mecillinam and Fosfomycin Minimum Inhibitory Concentration (MIC), association assay, invasion assay and survival assay. The sample that used to perform the experiments were taken from the urine of patients that has shown symptoms of urinary tract infection. From these methods, it was observed that there were two antimicrobials were effective in disrupting the E. Coli Bacteria and the MIC for the pathogen to be susceptible is very minimal.

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