World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

OPTIMIZATION OF PH IN THE LABELING OF APIGENIN WITH TECHNETIUM-99M RADIONUCLIDE AS A POTENTIAL RADICAL SCAVENGING AGENT

Danni Ramdhani*, Maula Eka Sriyani, Marisa Dwi Ariani, Eva Maria Widyasari

ABSTRACT

Objective. The aim of this research is to determine the pH optimization in the Technetium-99m labeling process with apigenin as a natural flavonoid compound. The antioxidant activity of apigenin can be used to detect the presence of excess free radicals in the body. The compound formed is expected to be a radiotracer compound for cancer diagnosis. Methods. The parameter used for optimization is the pH value. Determination of the optimum pH value can be evaluated from the radiochemical purity value of the 99mTc-Apigenin compound formed. Results. The results of pH optimization on the synthesis of 99mTc-Apigenin compound obtained the optimum pH value is 6 with a radiochemical purity value of 61.35%±4.56%. Conclusion. The best pH value for 99mTc-Apigenin synthesis was 6, with the least amount of impurities 99mTcO4 and TcO2 of 33.77% ± 7.73% and 4.88% ± 3.21%.

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