World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Dr. Uma Sudhakar, P. R. Koteshwari*, G. Manoj Kumar and T. Sangeetha


Objective: The objective of this article is to compare the antimicrobial activity of commercially available antiseptic mouth rinse and to determine the clinical relevance of the evidence. Materials and methods: Two mouth-rinses – Chlorhexidine 2% (CHX) and Listerine mouthwash were used to test among 20 individuals, by dividing them into two groups with 10 members in each group. Each individual were first tested by applying Disclosing agent before and after the use of mouth-rinse to check for plaque accumulation and to determine the amount of plaque reduction. Result: CHX 2% is still considered as the gold standard antimicrobial mouthwash because of its broad spectrum of bacterial activity and prolonged substantivity of approximately 12 h. Descriptive statistics including mean and standard deviation were calculated for two groups. T-Test was determined and the result was relatively significant at a value of P < 0.05. Conclusion: In the present study, Chlorhexidine is considered as most effective anti-microbial agent, compared with Listerine. And Chlorhexidine is best suitable for bed ridden patients compared to other commercially available mouthrinse in order to promote oral health, reducing oral plaque accumulation in them.

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