World Journal of
Pharmaceutical and Life Sciences

HEMATOLOGICAL AND SAME BACTERIAL INFECTIONS AS PARAMETERS IN THALASSEMIA PATIENTS

Asmaa Yahya Irzooqi*, Muthanna A. Saleh, Mohammed Abdul Daim Saleh

ABSTRACT

Background: Thalassemia is a genetic disorder of hemoglobin production, patient with thalassemia major and some intermediate needed regular blood transfusion for correction of anemia to keep hemoglobin level at lower limit enough for oxygenating tissues, Those patients have many complication from those anemia that threating their life. Objective: To evaluate some hematological and bacterial infection parameters such as urinary tract infection in splenectomized and non-splenectomized thalassemia patient. Materials and Methods: This clinical study had been done at Hematology center/ Baqubah Teaching Hospital from the period of 15 July 2018 to 19 April 2019. The total number of patient is sixty, thirty of them lifting the spleen and thirty others were not lifting the spleen as a study group was chosen according to the study criteria, and patients with viral hepatitis were excluded. All patients had been referred to hematology center after specialist physician requests. The main compliant was anemia. Detailed history of each patient was obtained concerning name, age, gender, address, degree of kinship, diagnosis, number of transfusion in month, date of spleen lift. Results: In our clinical study we compare between two groups of thalassemic patients. Regarding the age group we found the patients were aged between 1 to 39 years, with an average of 20 years. Decrease neutrophils in splenectomized group (26.95% ± 1.80) compared to control group (64.23% ± 1.01). Appearance different statically significant more prevalent in patients with splenectomized than those who non- splenectomized. Opsonized bacteria are removed efficiently by macrophages in the spleen and liver, poorly opsonized bacteria, such as encapsulated bacteria, are only cleared by the spleen. E. coli isolate (58%) in UTIs more distribution than other causative pathogenic bacteria. Conclusion: There are many parameters related with thalassemia appears between Iraqi people, from these, related with hematological, and physiological characteristics of patients.

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