DESIGN AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF METFORMIN BY NATURAL POLYMERS
The aim of the present study was to develop sustained release matrix formulation of Metformin to maintain constant therapeutic levels of the drug for over 12 hrs. Guar gum, Xanthane gum and Carbomer were employed as polymers. Formulations were prepared by wet granulation technique. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. From the dissolution studies it was evident that the formulation (F2) showed better and desired drug release pattern i.e., 99.65±0.05% in 12 hours. It contains the guar gum polymer. It followed Higuchi order release kinetics mechanism.[Full Text Article]
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