World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), Web of Science Group (Under Process), Directory of Research Journals Indexing, 

Abstract

DESIGN AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF METFORMIN BY NATURAL POLYMERS

Zeenath Ruhy*

ABSTRACT

The aim of the present study was to develop sustained release matrix formulation of Metformin to maintain constant therapeutic levels of the drug for over 12 hrs. Guar gum, Xanthane gum and Carbomer were employed as polymers. Formulations were prepared by wet granulation technique. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. From the dissolution studies it was evident that the formulation (F2) showed better and desired drug release pattern i.e., 99.65±0.05% in 12 hours. It contains the guar gum polymer. It followed Higuchi order release kinetics mechanism.

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