World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

OBESITY, INFLAMMATION AND METABOLIC SYNDROME

Saranya Mani* and Raskin Erusan

ABSTRACT

Obesity is rapidly increasing in countries like India. Currently it is seen as a pro-inflammatory state with a risk in inflammatory parameters such as Tumour necrosis factor- ? (TNF- ?) along with the increase in the secretion of leptin. Evaluation of these parameters in 20 control and 20 cardiovascular disease(CVD) subjects of normal and overweight BMI might enable us to understand the link between obesity, BMI, inflammation and CVD. In this connection, serum leptin, TNF- ? were measured using ELISA methods and serum triglycerides, cholesterol and lipid profile in normal and overweight BMI subjects were analysed. Interestingly leptin level was found to be higher in normal & overweight BMI of CVD subject. A profound positive correlation has been observed between obesity, serum leptin and TNF- ? suggesting a possible link between obesity, inflammation and metabolic syndrome.

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