World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), Web of Science Group (Under Process), Directory of Research Journals Indexing, 

Abstract

ORAL IN-SITU GEL: A REVIEW

D. S. Pawar*

ABSTRACT

The difficulties in oral drug delivery system prompted the researchers to design a drug delivery system which can stay in the stomach for prolonged and predictable time. One novel approach in this area is gastroretentive floating drug delivery system. Oral in-situ gel forming system provided a suitable way of providing the controlled delivery of drug within the stomach with enhanced gastric retention. This gives benefit of increased residence as well as sustained release. In-situ gel gives advantages such as ease of administration, reduced frequency of administration, improved patient compliance and comfort. In-situ gel formation occurs due to one or combination of different stimuli such as PH change, temperature modulation and ionic cross linking. In-situ gels are the solutions that undergo gelation after reaching the particular site due to physico- chemical changes. The gel formed from in-situ gelling system, being lighter than gastric fluids float over stomach contents due to the presence of bio adhesive nature of polymers resulting in prolonged gastric retention time.

[Full Text Article]

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