World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Scientific Indexing Services (SIS), Indian citation Index (ICI), Directory of Research Journals Indexing, Scintific journal impact factorScientific Journal Impact Factor (SJIF), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Cosmos Impact Factor, IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), Web of Science Group (Under Process), Research Bible, Fuchu, Tokyo. JAPAN, Scholar Article Journal Index (SAJI), Scope Database, Academia, 

Abstract

SYNTHESIS AND EVALUATION OF THE ANTIMALARIAL ACTIVITY OF CINNAMIC ACIDS DERIVED FROM PIPERIDINE

Rokhyatou Seck, Malamine Mansaly, Abdoulaye Gassama*, Christian Cavé and Sandrine Cojean

ABSTRACT

The synthesis and antimalarial activity of 1, 4-aminopiperidine derived cinnamic acids are described. Different analogs are prepared from reductive amination reactions and SN1 substitutions. These analogs are tested against chloroquino-sensitive strains 3D7 and chloroquine-resistant W2 plasmodium falciparum, cytotoxicity and selectivity are also evaluated. Thus, compound 14a showed excellent activity against both plasmodium falciparum strains [IC50 = 13.18 nM (3D7) and 18.96 nM (W2)] with a CC50> 100 and good selectivity index (> 15.6 (3D7) and> 10.8 (W2)). The molecules are characterized by NMR and mass spectroscopy.

[Full Text Article]   [Download Certificate]

WJPLS CITATION

  All Since 2019
 Citation  422  322
 h-index  9  7
 i10-index  4  2

SJIF Impact Factor 7.409  

INDEXING

Indexing

NEWS & UPDATION

    A PHP Error was encountered

    Severity: Notice

    Message: Undefined variable: news

    Filename: views/right_panel.php

    Line Number: 79

    A PHP Error was encountered

    Severity: Warning

    Message: Invalid argument supplied for foreach()

    Filename: views/right_panel.php

    Line Number: 79

BEST PAPER AWARDS

World Journal of Pharmaceutical and life sciences Will give best paper award in every issue in the from of money along with certificate to promote research .

Best Article of current issue

Download Article : Click here

Downloads

  Covering Letter

  Copy Right Form

  Author Instruction

read more

Powered By WJPLS ! All Rights Reserved.

WJPLS

Follow us on: