World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), Web of Science Group (Under Process), Directory of Research Journals Indexing, 

Abstract

PHYSICAL CHARACTERISTICS OF TABLET COMBINING GRANULES WITH DUTCH TEAK EXTRACT (GUAZUMA ULMIFOLIA (L).) AND GREEN TEA EXTRACT (CAMELIA SINENSIS (L.) O.K) WITH AVOCADO STARCH (PERSEA AMERICANA MILL.) AS BINDING AGENT

Wardiyah* and Tati Suprapti

ABSTRACT

Dutch teak Guazuma ulmifolia (L.) and green tea (Camelia sinensis (L.) O.K) are known for their use as antiobesity agents. The Dutch teak and green tea extract are produced through remaseration using 70% of alcohol. Avocado seed contains amylose and amylopectin compounds. Amylose content enables the extract to absorb water and has a good expanding capacity, which makes it possible to be employed as tablet break-apart agent. Amylopectin on the other hand, has the ability to form aggregate through inter-particle binding, therefore, it serves as a binding agent. The research is aimed at understanding the effect of avocado starch as a binding agent toward tablet’s physical characteristics, including weight homogeneity, hardness, friability, and break-apart time. Tablet is produced through wet granulation process with avocado starch as the binding agents (on 4 formulas) and two other agents, serving as control agent, namely PVP and gelatin. The obtained data is analyzed theoretically by comparing the result with the existing literature and statistically employing ANOVA one-way test, with 95% level of trust. Tablet with the best quality is produced from formula group of avocado starch with 5% concentration. As the concentration of avocado starch goes up, the flow time also runs up, as well as the humidity level, hardness and break-apart time on granule, Dutch teak extract, and green tea extract. A significant difference among the six formula occurs on the test of hardness, friability, break-apart time, and some size homogeneity tests, which is indicated by the value of p < 0.05.

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