World Journal of
Pharmaceutical and Life Sciences

ANTIDIABETIC ACTIVITY OF ETHANOLIC EXTRACT OF SAPINDUS EMARGINATUS LEAVES

T. Santhi Priya*, G. Pitchaiah and D. Dhachinamoorhti

ABSTRACT

The pharmacological and acute toxicity studies of ethanolic extract of Sapindus Emarginatus Leaves was performed by following, OECD-423 guidelines (Acute toxic class method). No mortality or acute toxicity was observed up to 2000mg/kg of body weight. The Biological dose of extract Sapindus Emarginatus dose was selected 200mg/kg and 400mg/kg in this dose possessed significant antidiabetic activity.In conclusion, in the present study on the ethanolic extract of Sapindus Emarginatus leaves having antidiabetic activity more over nearest activity of Glibenclamide. This study shows that flavanoids present in this extract may be possibly responsible for the antidiabetic activities. Further pharmacological and biochemical investigation are to be done to find out the active constituent responsible for the antidiabetic activity. However, the future study may also include cataloging, standardizing, for quality control and above all developing new drugs/ pharmaceuticals keeping the disease and cost factor in view.

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