World Journal of
Pharmaceutical and Life Sciences

COMPARABLE EFFECT OF DIFFERENT ERYTHROPOIETIN PLASMA LEVELS IN PATIENTS WITH CHRONIC RENAL FAILURE

Hayder Abdulhafedh Kurji*, Hayder Al-Anbari, Qutaiba Ahmed Ibrahim, Fatimah Kadhim Al Mahdawi, Mazin Razooqi Mohammed and Nabeel Khalid AL-Wandi

ABSTRACT

Introduction: The kidney is the main site for the synthesis of Erythropoietin, which represents the circulating hormone responsible for stimulatory effect on bone marrow for the erythropoiesis. In case of chronic kidney disease (CKD), Erythropoietin deficiency is the main cause of anemia. Erythropoietin synthesis by DNA technology results in revolution in the management strategies of anemia in CKD. This study aimed to evaluate the effect of different doses (different serum concentration) of erythropoietin on anemia treatment outcome in different stages of renal disease. Material and methods: this prospective study was conducted on 245 patients categorized into three groups according to their stage of renal disease. Serum concentration of Erythropoietin, HGB, Transferrin, Ferritine, RBC, and hsCRP were measured using spectrophotometric and immunochemical procedures. Results: There was a significant reduction in hematocrit, HGB in patients with advanced stage kidney disease in comparison to early stage p=0.00567, p=0.00533. Transferrin was significantly less in stage V in comparison to early stage of renal disease p=0.00635. Ferritin was significantly higher in stage V comparing to that of early stage of renal disease. Serum concentration of erythropoietin was directly correlated with hematocrit and Hb in early stage of renal disease EP0 R² = 0.597 Hct, R² = 0.674 HB, whereas, in patients with stage 5 renal disease, erythropoietin is poorly correlated with hematocrit and Hb, EP0 R² = 0.05353 Hct R² =0.064 HGB. Conclusion: Advanced renal failure is associated with lack of erythropoietin and consequently result in severe anemia. The stimulatory effect on bone marrow by erythropoietin is reduced with progression of renal disease.

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