World Journal of
Pharmaceutical and Life Sciences

WOUND HEALING ACTIVITY OF METHANOLIC EXTRACT OF EUPHORBIA NIVULIA IN ALBINO RATS

S. Gopi Krishnan*, N. Balakrishnan, Sanjeevi Raja S., Micheal Jessica A., Vinith Kumar J. and Joselin A. S.

ABSTRACT

A medicinal plant are used with the intention of maintaining health, to be administered for a specific condition, or both, whether in modern medicine or in traditional medicine. Plants have been used for traditional medicinal purpose for long before pre historic period. Recently world health organisation estimated that 80% of the people in worldwide on herbal medicines for some aspects of their primary health care needs. According to WHO, around 21,000 plant species have the potential for being used as a medicinal plants.[1] The main objective of the study was to evaluate the wound healing activity of methanolic extract of euphorbia nivulia in albino rats. The dried powdered euphorbia nivulia were for ointment preparation. The selected albino rats were used for wound healing animal model experiment, approved by institutional ethical committee. Both incision and excision wound were made by cutting a skin from the dorsal abdomen region. Wound healing parameters includes contraction rate of wound and regeneration of tissues at the site of wound. Euphorbia nivulia extract posses a significant wound healing ability when compared to control, using soframycin as standard drug. It was concluded that the wound healing activity is due to the presence of its active principles, which accelerate the healing process and confer tensile strength to the healed wound.

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