Abstract
A BEGINNERS’ GUIDE TO CORI’S DISEASE
Hijab-E-Zainab, Sakina Ali Sheikh and Sikander Ali*
ABSTRACT
Diseases that are related to the metabolism of Glycogen are called Glycogen Storage Diseases. These diseases are genetically inherited disorders that can be categorized into 10 subtypes depending on the deficiency or improper functioning of a particular enzyme. The deficiency of Glycogen debranching enzyme causes several malfunctions in the body that are particularly characterized under the reference of GSD type-III or Cori’s disease or Forbe’s disease. The main symptoms include hypoglycemia, hepatomegaly, weight loss etc. This disease can be significantly divided into four subtypes depending on the phenotypic variability of the gene. Types IIIa and IIIb are more common, other types include IIIc and IIId. Also, the extent or the severity of the disease can vary according to the type of tissues in which glycogen is deposited i.e., hepatic, cardiac, skeletal or gastrointestinal. The only possible way to control the disease is through proper intake of proteins, carbohydrates, and fats.
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