World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), Web of Science Group (Under Process), Directory of Research Journals Indexing, Scholar Article Journal Index (SAJI), International Scientific Indexing ( ISI ), 

Abstract

TETRAMETHYLPYRAZINE DIMER ALLEVIATES APP PROCESSING AND TAU HYPERPHOSPHORYLATION IN NEURO2A/APPSWE CELLS

*Xiaoyi Lin, Xifei Yang* and Xianfeng Huang*

ABSTRACT

Alzheimer's disease (AD) is a common neurodegenerative disease whose two major pathological features are ?-amyloid (A?) aggregation and tau hyperphosphorylation. Tetramethylpyrazine is an alkaloid monomer extracted from Chuanxiong, which has specific pharmacological effects such as improving learning and memory and protecting nerves. Here, we evaluated the neuroprotective effect of a newly synthesized tetramethylpyrazine dimer (DTMP) using the murine neuron-like cells (N2a) transfected with the human "Swedish" mutant amyloid precursor protein (N2aAPP). the half-inhibitory concentration (IC50) of DTMP against N2a/APPswe cells was 12.37 ?M as measured by cell proliferation-toxicity assay (CCK-8). Western blot analysis showed that DTMP treatment significantly reduced the expression of BACE1, PS1 and t-APP in the APP pathway and attenuated the phosphorylation levels of Ser396, Ser262 and Thr231 in Tau protein. The modulation of dysregulated proteins implicated in AD pathogenesis implies the pharmacological mechanisms of DTMP and its potential as a novel therapeutic choice in AD.

[Full Text Article]

BEST PAPER AWARDS

World Journal of Pharmaceutical and life sciences Will give best paper award in every issue in the from of money along with certificate to promote research .

Best Article of current issue

Download Article : Click here