World Journal of
Pharmaceutical and Life Sciences

THE RELATIONSHIP BETWEEN SERUM SEX HORMONES WITH PROSTATIC VOLUME

*Dr. Othman Jasim Mohammed Alzaidy, Dr. Ali Kamal M. Sami and Dr. Diar Hameed Bajalan

ABSTRACT

Background: Previous epidemiologic investigations of the associations of sex-steroid hormones and benign prostatic hyperplasia have focused on predominately American-European populations. The objective of this study was to evaluate potential associations of body mass index and endogenous sex-steroid hormones with prostate volume in a population-based sample of Iraqi men, ages 13–89 yr. Aim of study: To describe relationship between prostate volume with: age, body mass index, serum prostatic specific antigen, Dihydrotestosterone, estradiol, testosterone and progesterone. Patients and method: Eighty patients have been selected from May 2012 to April 2013 in Sulaimanyah teaching hospital, they were divided into eight groups of 10(patients) each, according to their age. All groups were sent for the following: serum prostatic specific antigen, serum testosterone, serum dihydrotestosterone, serum progesterone, serum estradiol and body mass index were calculated for them, prostate volume were measured by abdominal ultrasound, but trans-rectal ultrasound of prostate volume were not done. (Any patient suspected for CA-prostate excluded after sending for serum prostatic specific antigen and digital rectal examination which was done in any suspected patient). Results: It was found that prostate volume(range from 14-65g)is directly related to increase in age(range from 13-89yrs), also increase in body mass index(which range from 15.7-30.9) is independently related to increase in prostate volume, also increase in serum estradiol (range from20-50pg/ml) is related to increase in prostate volume, increase in prostate volume is related to increase in serum prostatic specific antigen(range 0.22-4.2ng/ ml),while it is related to decrease in serum testosterone (range 2.5-10 ng/ml), serum dihydrotestosterone (range21-246pg/ml) and serum progesterone (range 20-92pg/ml). Conclusion: The natural history of BPH reflects both pathologic and clinical sequelae of cumulative exposures to a complex of sex-steroid hormones, growth factors, and binding proteins. The Sulaimanyah men’s health study of Iraqi men highlights the importance of age and body composition and the hormonal determinants of prostate volume. In our research we found that our result is similar to other researches done in other centers, also our study is compatible with other researches in making basic information ground for evaluation of benign prostatic hyperplasia.

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