World Journal of
Pharmaceutical and Life Sciences

COORDINATION COMPOUNDS AS RADIOPHARMACEUTICALS

*Ibrahim Waziri, Usman Umaru and Ibrahim Mohammed

ABSTRACT

The interest in radiopharmaceutical as a positron – emitting radionuclide has grown considerably over the last decade, due to the fact that some radioisotopes have a standardized production and suitable half – life, favourable decay characteristics for single photon emission computed tomography or positron emission tomography (SPECT/PET) and successful use in a different diagnostic and therapeutic applications. There are a few radiopharmaceuticals dependent on monoclonal antibodies, peptides and particulate labelled with suitably used isotopes of radiometals for the treatment of some cancer and arthritis. However, to be utilised effectively in SPECT/PET applications, it must be stably bond to a targeting ligand. This review focuses on the coordination compounds as radiopharmaceuticals, six out of many radiometals were considered and the most successful used isotopes of the already discussed radiometals are; 99Tc, 186Re, 64Cu, 90Yt, 89Zr and 199Au chelators due to stability of their atomic properties such as half – life and favourable decay properties.The advancement of new radiometal ligands for SPECT/PET is a functional area of research. The review also dwells on the design principles and mechanism of radiopharmaceutical among the coordination compounds.

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