World Journal of
Pharmaceutical and Life Sciences

THE STUDY AND EVALUATION OF DRUGS IN RENAL IMPAIRED PATIENTS IN TERTIARY CARE HOSPITAL

Deeba Shaista*, S. K. Syed Hussain, Dr. Mohammed Ashfaq Hussain, Dr. Anupama Koneru and Imrana Siddiqua

ABSTRACT

In our study we have studied and evaluated the drug dose management of renal impaired patients in the Prime Hospital Hyderabad. In the present study of 250 patients, 109 (43.6 %) were male and 141 (56.39 %) were female. In our study it was found that renal impaired patients were more prevalent in females than males. Evaluation of GFR stages showed that out of 250 patients, 72 (28.80%) were of stage 3, 150 (60%) were of stage 4 and 28 (11.20%) were of stage 5. In our study 72 (28.79%) patients are under GFR stages iii. (60-30 GFR mL/min). 150 (60%) GFR stages iv. (30–15 GFRmL/min) and GFR stages v. 28 (11.20%) (15–0 GFR mL/min). In our study, out of 250 patients, out these patients, 90 (36%) were suffering from hypertension. Other concomitant conditions were electrolyte imbalances in 42 patients (16.8%), anaemia in 24 patients (9.6%), cardiovascular disorders in 15 patients (6%), diabetes mellitus in 24 patients (9.6%), liver disorders in 32 patients (12.8%), chronic glomerulonephritis in 18 patients (7.19%) and retroviral disease in 5 patients (2 %). Interventions on account of our observations we found out that the major drugs to be avoided for renal impaired patients are, Nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac, ibuprofen, and indomethacin, Selective COX-2 inhibitors. Pethidine, cefepime, metformin, spironolactone should not be administered to renal impaired patients, because the renal-dependent metabolite, normeperidine may leads to cerebral convulsions. Patients with renal insufficiency needs high amount of initial dose of antibiotics. Start with the normal dose, then the maintenance dose is adjusted to renal function depending on its half-life. The need of dialysis is to patients with severe hyperkalaemia and unresponsive to medical therapy and drug overdose with a dialysable toxin.

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