World Journal of
Pharmaceutical and Life Sciences

EVALUATION OF ANXIOLYTIC AND ANTIDEPRESSANT ACTIVITIES OF ASHWAGANDHA CHURNA IN MICE

V. Kaveri, B. V. Pushpalatha, V. Sailuja, K. Subashree, S. Umayal and K. Karthigadevi*

ABSTRACT

The current study was explored to evaluate the anxiolytic and antidepressant activities of Ashwagandha churna in mice using various animal models of anxiety and depression. The anxiolytic activity was evaluated in elevated plus maze (EPM) and Actophotometer test and the anti-depressant activity was evaluated in forced swimming test (FST) and Tail suspension test (TST). The efficacy of ashwagandha churna was compared with the standard anti-anxiety (diazepam 2 mg/kg,p.o) and anti-depressant (imipramine – 5 mg/kg, p.o) drugs. Result shown that the ashwagandha churna at the dose of 400 mg/kg on 5th day of drug treatment is as effective as standard drugs used in anti-anxiety and anti-depressant activities in mice by increased time spent and entries to open arm in EPM model, decreased locomotor score (Actophotometer test) and decreased immobility time in FST and TST model respectively. Hence it can be concluded that ashwagandha churna may be used as a potent therapeutic agent for treating anxiety and depressive disorders.

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