World Journal of
Pharmaceutical and Life Sciences

BACTERIOLOGICAL PROFILE OF NEONATAL SEPTICEMIA, ASSOCIATED RISK FACTORS AND ANTIBIOTIC SUSCEPTIBILITY PATTERN OF THE ISOLATES

Tanya Mahindroo, Kalpana Date* and Vilas Thombare

ABSTRACT

Introduction: Neonatal sepsis or sepsis neonatorum refers to systemic infection of the newborn and is broadly divided into two types according to age of onset: Early onset sepsis (<72 hours of birth) – is acquired during fetal life, delivery or at the nursery and Late onset sepsis (>72 hours of birth) – is generally caused by microorganisms acquired from the environment rather than from the mother. Materials and methods: blood culture samples of clinically suspected cases of neonatal septicemia from December 2015 to May 2017 were studied and Antibiotic sensitivity pattern of the isolates was analysed. Results: Out of 155 cases, Blood culture positivity was seen in 48 (30.97%) samples. Of these 48, 30 were EOS and 18 were LOS. In EOS cases, Pseudomonas (23.33%) was the most commonly found organism and in LOS, Klebsiella (27.78%) and Candida (27.78%) were the most commonly found organisms. Maternal risk factors PROM and Perinatal fever were significant indicators of neonatal septicaemia with P-values of 0.0001 and 0.016 respectively. The neonatal risk factors i.e. prematurity and low birth weight were found to be statistically significant with P-values of 0.020 and 0.0001 respectively. Pseudomonas showed 70% sensitivity to Amikacin, Gentamycin, Imipenem and Tobramycin followed by 60% sensitivity to Levofloxacin and Piperacillin-tazobactam and 40% to Cefotaxime and Ceftazidime. Klebsiellashowed 66.67% sensitivity toAmikacin, Meropenem and Piperacillin-tazobactam followed by 50% sensitivity to Ceftriaxone and Ceft-sulbactam each, 33.33% sensitivity to Ceftazidime, Levofloxacin and Netillimycin each.

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