World Journal of
Pharmaceutical and Life Sciences

INTERLEUKIN-6 LEVELS ANN UNSTABLE ANGINA

Sadia Najeeb, *Dr. Fatima Tuzahra and Fateen Ahmad

ABSTRACT

Objective: To determine the frequency of raised Interleukin-6 levels in cases presenting with unstable angina. Methodology; In this cross sectional study, carried out at Holly Family Hospital, Rawalpindi during October 2017 to March 2018. In this study the cases with age more than 35 years irrespective of gender were included. Unstable angina was labelled according to presence of pain of 5 or more on visual analogue scale present at the centre of the chest, crushing or pressing in nature and persisting for less than 30 minutes and cardiac enzymes i.e. trop T falling in its normal limit irrespective of ECG changes. Raised value of IL-6 was labeled when it was > 5 ng/ml. Results; In this study there were total 100 cases of unstable angina with mean age 57.34±8.67 years with age range of 35 to 79 years. There were 32 (32%) cases with DM and 38 (38%) had HTN. Raised IL-6 levels were noted in 61 (61%) cases. There was no significant difference in terms of gender regarding raised IL-6 with p= 0.49. IL-6 was significantly high in cases with DM and HTN where they were noted in 24 (75%) and 29 (76.31%) cases with p values of 0.01 each. Conclusion; Raised Interleukin-6 level is seen in every 2 out of 3 cases and it is significantly high in cases of HTN and DM.

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