World Journal of
Pharmaceutical and Life Sciences

A COMPARATIVE STUDY ON THE COMBINATION USE OF INDACATEROL WITH GLYCOPYRRONIUM AND FORMOTEROL WITH TIOTROPIUM IN COPD PATIENTS IN A TERTIARY CARE HOSPITAL

Mathew George, Lincy Joseph, Jyothis Mary Joseph*

ABSTRACT

Objectives: The objectives of the study is to assess the symptomatic improvement and frequency of exacerbation in COPD patients and therby evaluating the effectiveness od both the combinations and to evaluate the quality of life of COPD patients, Also to assess the medication adherence and safety profile of these combinations inCOPD patients. Methods: This is a prospective observational studystudy conducted in 70 patients diagnosed with COPD. The study population was divided into two groups. In each group, 35 patients were enrolled. One group included the patients who were taking Indacaterol with Glycopyrronium 110/50?g and the second group taking Formoterol with Tiotropium 6/9?g. The SGRQ score, QOL score, Medication adherence and adverse effects were measured at beginning and at the end of 4 weeks. Results: The Indacaterol with Glycopyrronium and Formoterol with Tiotropium are effective in COPD patients, but significantly more difference was seen with Indacaterol with Glycopyrronium. As it shows more improvement in the SGRQ score , QOL score, Medication adherance and lesser number of adverse effects was seen with Indacaterol with Glycopyrronium.p value is significant .(p<0.0001). Conclusion: Both Indacaterol with Glycopyrronium and Formoterol with Tiotropium are effective in COPD patients. Both of them show improvement in SGRQ score and QOL score .Indacaterol with Glycopyrronium was found to be more effective in improving SGRQ score and QOL, Also the frequency of adverse effects was lesser with Indacaterol with Glycopyrronium. Thus this study throws light on the fact that Indacaterol with Glycopyrronium should be preferred over Formoterol with Tiotropium.

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