World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

CIGARETTE SMOKING IS THE LOWER RISK OF PARKINSON DISEASE

Suresh Undati*, Madhuri Boompally, Saikumar Manneboina, Srikanth Kotari

ABSTRACT

Parkinson disease is the one of the most common neurologic disorder, affecting approximately 1% of individuals over than 60 years causing progressive disability that can be slowed, but not halted, by treatment. As a major component of tobacco smoke, nicotine has been proposed to be asubstance for preventing against Parkinson disease risk. With a key role in regulating straital activity and behaviours mediated through the dopiminergic system. Animal studies also showed that nicotine could modulate dopamine transmission and reduce levadopaenduced dysakinesias. However, previous clinical trials yield contaversial results regarding nicotine treatment. In this review, we updated epidemiological, preclinical and clinical data, and studies on nicotine from diet.

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