World Journal of
Pharmaceutical and Life Sciences

BIODISTRIBUTION AND TOXICOLOGICAL EVALUATION OF NANOCONSTRACT OF BENDAMUSTINE

Shweta Dutta*, Vijay Kumar Singh, Deepak Kumar Dash

ABSTRACT

The present works deals with the biodistribution and toxicological evaluation of nanoconstruct of Bendamustine. Bendamustine is a most common alkaliting agent used in treatment of cancer. As per the previous studies indicates that anticancer drugs produce toxicity, by affecting on normal cells. Bendamustine is a well stabilized drug for cancer treatment with various formulations. Main objectives of present work were to, Improve biodistribution parameters and reduce toxicological parameters of the nanoconstruct of bendamustine. Were prepared of nanoconstruct of bendamustine with emulsification method by using chitosan and mannose were chitosan work as biodegradable polymer and mannose as ligand. Were characterizations, toxicological evaluation and biodistribution performed in prepared nanoconstruct. Were the characterization of nanoconstruct by SEM, Zitasizer, toxicology and biodistribution were performed by using Albino wistar rat in different groups. The result show that a prepared nanoconstruct was less toxic and it’s also alters the biodistribution parameters as compared pure drug of bendamustin.

[Full Text Article]   [Download Certificate]