World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

BIOACTIVITY AND FREE RADICAL SCAVENGING ABILITY OF AN ISOLATED TRITERPENOID SAPONIN FROM THE ROOT BARK OF MASSULARIA ACUMINATA SPP

Uduak S. Ukekpe* Harami M. Adamu, and Eno O. Ekanem

ABSTRACT

triterpenoid saponin was isolated from the methanol extract of the root bark of Massularia acuminata spp. The compound was identified as 3-O – ?- D- glucopyranosyl – (1-4)- ?- D- glucopyranosyl – (1-4)- ?- Dglucopyranosyl- olean -12-en-28-oic acid on the basis of chemical and spectral evidence of IR and NMR (1H, 13C, DEPT, 1H-1H COSY, HSQC and HMBC) data. The compound showed good inhibitory activity against the microorganisms, Salmonella spp, Staphylococcus aureus, Escherichia coli, Aspergillus niger and Candida albicans indicating that it is a bioactive compound. It was also found to possess antioxidant property by virtue of its high DPPH free radical scavenging ability of 73.09% at 100?g/ml, property that can make it relevant in stress management and cosmetic industry.

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