World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Nousseiba Abed*, Amina Benhammouda, Ryma Kriba, Asma Mosbah, Abdelkader Rouabah and Leila Rouabah


Objective: To determine the effects of Nigella sativa seeds on primary dysmenorrhea. Methods: This was a prospective study. Participants were 70 students with primary dysmenorrhea from University of Brothers Mentouri, Constantine who were divided into five groups. The control group and the ibuprofen group received 400 mg ibuprofen capsules. The third, fourth and fifth groups was administered orally respectively by Nigella sativa at 1g, 2g and 3g a day. The intervention continued for two consecutive menstrual cycles. During the first three days of menstruation. Data were collected from the students using a self-reported questionnaire and a visual analogue scale. Results: The results indicate that, after treatment, there were an improvement of systemic symptoms associated with dysmenorrhea compared to the control group in ibuprofen group and Nigella sativa groups respectively. Differences were significant in improvement of nausea (p< 0.05), breast pain (p< 0.001) and irritability (p< 0.01). In the control group, pain severity decreased from 4,94 at baseline to 3,66 in the second cycle, whereas that in the Ibuprofen group decreased from 7,90 to 1,80. That in Nigella sativa seeds groups also decreased from 6,57 to 3,85 , from 5,21 to 2,42 and from 6,42 to 2,07 about different doses 1g, 2g and 3g respectively. Differences were significant. Conclusion: Nigella sativa was as effective as ibuprofen in relieving pain and systemic signs in students with primary dysmenorrhea.

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