World Journal of
Pharmaceutical and Life Sciences

QUANTITATIVE ESTIMATION OF DEXAMETHASONE DRUG BY USING UV VISIBLE SPECTROSCOPY

*Dipali Deshmukh, Akash Pathare, Suksham Sudan, Sumit Kumar Gupta, Suraj Balpande, Sushil Pal, Swastik Thakur, Tushar Sahu, Dr. Jagdish Chandra Rathi

ABSTRACT

In this study, it was concluded that the content of Dexamethasone in the marketed tablet formulation was found to be within the specified limits as claimed by the manufacturer. The analytical data obtained confirmed that the developed UV-spectrophotometric method provides accurate and reproducible results, fulfilling the acceptance criteria set for assay determination. The precision and reliability of the method ensure its suitability for routine pharmaceutical analysis. The content of Dexamethasone was found to be 99% (0.495mg) at wavelength of 230nm. Std. show absorbance 0.753 at 230nm at 230nm wavelength and sample shows absorbance 0.782 at 230nm, which indicates accuracy in result. This study highlights the efficiency of UV-spectroscopy in both qualitative and quantitative determination of Dexamethasone in tablet dosage forms. It can be used effectively to monitor the quality and stability of the drug in various formulations. Furthermore, this method minimizes analytical errors, reduces solvent consumption, and supports environmentally friendly analytical practices. Overall, UV-spectrophotometric analysis stands as a powerful and dependable analytical tool for assessing the purity, potency, and efficacy of Dexamethasone in pharmaceutical preparations. The findings confirm that the developed method can serve as a valuable technique for regular quality control analysis in academic, industrial, and research laboratories.

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