World Journal of
Pharmaceutical and Life Sciences

A PROSPECTIVE STUDY ON THERAPEUTIC DRUG MONITORING OF DIABETES MELLITUS IN GOVERNMENT AREA HOSPITAL

Anitha Pendyala*, Sri Lakshmi Surekha Manchineni, Hephzibah Palli, Karthika Pamidipalli and Prasadarao Manchineni

ABSTRACT

Introduction: For patients with diabetes mellitus, a comparison between TDM and standard medication therapy is
essential to comprehending the benefits, drawbacks, and clinical consequences of each. Conventional therapy
offers standardized treatment regimens and simplicity, while target-directed medicine (TDM) delivers personalized
care, improved safety profiles, and optimum therapeutic results. Healthcare professionals can determine the best
course of action for their patients by weighing the effectiveness, safety, clinical results, and cost-efficiency of both
approaches. Methods and Material: The Present study was prospective observational study conducted at
Department of General medicine Government area hospital, Narasaraopet. This study was conducted on 102
patients. A total of 102 patients were recruited for this 45-day prospective study, with 51 patients assigned to the
TDM group and the remaining 51 patients assigned to the conventional treatment group. The primary outcome
measure for the study will be the change in HbA1c levels from baseline to the end of the 46-day period. Secondary
outcome measures will include changes in blood glucose levels, medication adherence, and adverse events.
Results: In this study, 35 – 45 years of male are being dominated with sample of 40 (39.21%) followed by 46-60
years male with sample of 36 (35.29%). The study found that patients who underwent therapeutic drug monitoring
had a greater reduction in mean blood glucose levels (from 175 mg/dL to 110 mg/dL) compared to patients who
received conventional treatment (from 170 mg/dL to 120 mg/dL). There is decreasing of the HbA1C levels from
7.2% to 5.9%, But there is worthy more changes in Therapeutic drug monitored patients from 7.1% to 4.6%.
Conclusion: The results of the study indicated that patients in the TDM group achieved significantly better
glycemic control compared to the conventional treatment group.

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