World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

METHOTREXATE OVERDOSE WITH BONE MARROW TOXICITY: A CASE REPORT

Anza A. S.*, Dona Benny, Arathy R. and Sini S. G.

ABSTRACT

Methotrexate (MTX) is a disease-modifying anti-rheumatic drug that has been used widely in dermatology, oncology and rheumatology fields. Our study concentrates on a fifty year old male patient who had developed MTX overdose with bone marrow toxicity by accidental intake of the drug continuously for a week. The patient developed neutropenic fever, oral mucosal ulcer and rashes along with increased serum aminotransferase and reduced count of leukocytes and platelets. With the diagnosis of MTX overdose, the drug was discontinued and the patient underwent treatment with leucovorin, granulocyte colony-stimulating factor and empiric broad spectrum antibiotics (Meropenem and Teicoplanin). Co-existing conditions were treated accordingly.

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