World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

FORMULATION DEVELOPMENT, OPTIMIZATION AND EVALUATION OF FAST DISSOLVING ORAL FILMS OF VERAPAMIL HYDROCHLORIDE

Khan Juber*, Kazi Usama, Patel Fayam, Patel Raihan, Shaikh Afsar and G. J. Khan

ABSTRACT

Fast dissolving drug delivery system offers a solution for those patients having difficulty in swallowing tablets or capsules etc. The film dissolves quickly when placed in mouth without need of water thus helpful in providing rapid onset of action. Verapamil is a calcium channel blocker used as an antianginal, antiarrhythmic, and antihypertensive agent with extensive first pass metabolism which results in less bioavailability. The present study was aimed to formulate fast dissolving oral films of verapamil to enhance bioavailability and avoid pre-systemic metabolism and improve patient compliance. The fast-dissolving strips were prepared by solvent casting technique with the help of HPMC E5 and Pullulan. The strips were evaluated for film thickness, tensile strength, folding endurance, in vitro disintegration time, surface pH, drug content uniformity and in vitro dissolution studies. Official criteria for evaluation parameters were fulfilled by all formulations. Based on the evaluation parameters, the formulation F4 showed optimum performance against other formulations; hence formulation F4 was selected as optimized formulation.

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