World Journal of
Pharmaceutical and Life Sciences

FORMULATION DEVELOPMENT OF ETORICOXIB TABLETS: EFFECTS OF β-CYCLODEXTRIN AND-SOLUTOL HS15 COMBINATION BY 22FACTORIAL DESIGN

Lingaraj S. Danki* and G. V. Suresh Kumar

ABSTRACT

Etoricoxib, a widely prescribed anti-inflammatory drug belongs to class I? under BCS and exhibit low and variable oral bioavailability due to its poor aqueous solubility. It is practically in soluble in water and aqueous fluids. As such its oral absorption is dissolution rate limited and it requires enhancement in the solubility and dissolution rate for increasing its oral bioavailability. The objective of the present study is to enhance the solubility and dissolution rate of etoricoxib by the use of ?-cyclodextrin (?CD) and Solutol HS15 (non ionic surfactant). The individual main effects and combined (or interaction) effect of ?CD (Factor a) and Solutol HS15 (Factor b) in enhancing the solubility and dissolution rate of etoricoxib from tablets were evaluated in a 22 factorial study. The objective of the present study is optimization of etoricoxib tablet formulation employing ?-CD, Solutol HS15 by 22 factorial design. Four tablet formulations wee prepared using selected combinations and etoricoxib tablets were prepared by wet granulation technique and were evaluated. The tablet formulations hardness were ranging from 6.5-7.0kg/sqcm. The friability values are ranging from 0.040-0.80%. Disintegration time is ranging from 1.0-2.5mins. The tablet formulation E1 gave dissolution of etoricoxib 7.55 at 30 mins. The tablet formulations E2(a) and E3(b) gave dissolution of etoricoxib 33.10 and 44.92 at 30 mins respectively. Where as tablet formulation E4(ab) gave rapid dissolution of 64.95% at 30 mins. The increasing order of dissolution rate (K1) observed with various formulations was E1 [Full Text Article]   [Download Certificate]