World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

A REVIEW ON MICROSPHERES PREPARATION AND EVALUATION METHODS AND DRUG PROFILE OF BENAZEPRIL ROLE IN LOWERING BLOOD PRESSURE

Kerryn Joseph A. D., Suresh N.*, Preethi Fernandiz, S. Srinivasan

ABSTRACT

Microparticles are designed to control drug release into the skin to ensure that the drug remains localized at the application site. It act as reservoir releasing an active ingredient over an extended period of time maintaining effective drug concentration in the skin and at the same time, reduces the undesired side effects. Oral controlled drug delivery system is designed to achieving more predictable and increased bioavailability, thereby obtaining a maximum therapeutic effect. The design of oral dosage pharmaceutical formulation, empty the process can last from a few minutes to 12 hours. The Rapid GI transit can prevent complete drug release in the absorption zone and reduce the efficacy of administered dose since the majority of drugs are absorbed in stomach or upper part of small intestine. Thus placement of drug delivery system in a specific region of the GI tract offers a numerous advantages especially to the drugs having narrow absorption window, stability problem in intestine, poor solubility in alkaline PH, local activity of in stomach and property to degrade in colon. Therefore the design of a sustained release preparation requires both prolongation of gastrointestinal transit of dosage form as well as controlled drug release. Benazepril is a class of medications called angiotensin-converting enzyme inhibitors. It acts by decreasing certain chemicals that tighten the blood vessels, so blood flows more smoothly. Benazepril is used in combination with other medications to lower the high blood pressure.

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