World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Almudena Sánchez Martín, Angel San Miguel Rodríguez, Julia San Miguel Rodríguez, Angel San Miguel Hernández* and Carmen Lozano Estevan


Introduction: Food-drug interactions are unknown in many cases by health professionals, which modifies their therapeutic action. Objectives: To provide sufficient information on the interactions that occur when administering a food when the patient is taking a drug and to prevent it from their joint consumption has clinical significance. Material and method: A literature review was carried out in the Medline (pubmed) databases, in the Pubmed and Scielo databases. The only filter used was language, searching only articles written in Spanish and English. All types of studies have been included except AMI with alcohol. Results: Out of a total of 285 articles, a total of 133 have been included in this review. Of them, 39 describe the main AMI that decrease the therapeutic effect of drugs due to various mechanisms of action and 28 the main AMI that increase the effect. drug therapy. Food-drug interactions can be inhibitors or enhancers of the therapeutic action of drugs, in many cases, these interactions can lead to the administered drug becoming toxic or, on the contrary, not exerting the expected therapeutic effect. Discussion: It is a subject of great study but health professionals who have a low degree of knowledge of AMI to guarantee a better therapeutic treatment. Conclusion: The fact that there is an interaction is not always negative and can sometimes be used for the benefit of therapy. To quickly reach high therapeutic levels, medications must be administered outside of meals with a glass of water. On the contrary, if the drugs cause gastric irritation or if you want to delay their action or achieve lower plasma levels, the drugs should be administered with food.

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