World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Hala A. Khoriba*, Maha A. Niazy and Doaa A. El Sharkawy


Objective: This clinical trial was designed to evaluate the anti-cariogenic effect of Miswak and Grape seed extract (GSE) in comparison to fluoride. Materials and Methods: GSE 6.5% and sodium fluoride 0.05% mouthwashes were prepared before beginning of the study. 30 patients were allocated randomly into three groups; (n=10) M1: used Miswak sticks, M2: rinsed with (6.5%) GSE mouthwash, and M3: rinsed with (0.05%) sodium fluoride mouthwash. Patients used their treatments for 2minutes, twice per day for three months. Unstimulated saliva sam-ples were collected at baseline, after one month and after three months. The bacterial count was assessed through streptococcus mutans culturing, and colonies forming units were counted. Saliva buffering capacity (BC) was as-sessed using a quantitative method using a hand-held pH meter. Data were statistically analyzed, and the signifi-cance level was set at p ?0.05. Results: All groups showed a significant decrease in bacterial count by time. There was no significant difference in bacterial count between groups after one month. After three months miswak and GSE significantly decreased bacterial count compared to fluoride. By time, GSE showed a significant decrease in saliva buffering capacity while, miswak and fluoride showed non-significant decrease in saliva buffering capacity. Conclusion: The antibacterial effect of the tested materials is time dependent, while having a negative effect on saliva buffering capacity being prominent with GSE.

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