World Journal of
Pharmaceutical and Life Sciences

INSILICO STUDY OF QUINAZOLINE-4-ONE ON SARS-COV 3CL PROTEASE

Kavitha K.*, Mohan S., Srinivasan N., Suresh R. and Vismaya K. V.

ABSTRACT

In the world wide presently severe panics caused by Severe Acute respiratory syndrome (SARS), Middle East respiratory syndrome – coronavirus.and Middle-East Respiratory Syndrome-Corona virus. Think about that, the researchers targeting these viruses have been required. Assortment literature quinazolinone derivatives exhibited antiviral activity and Corona viruses (Co-Vs) have been raising targets of some quinazolinone. The antiviral activity of quinazolinone against CoVs is assumed directly caused by inhibiting 3C-like protease (3CLpro). In this, we applied a newly designed quinazolinone compounds to systematically investigate binding affinity of compounds against SARS-CoV 3CLpro. The interaction of the newly designed compounds QC1-QC8 against 6M2N enzyme five quinazolinone an induced-fit docking analysis indicated are more involved in binding affinity. The present study aimed at studies showed with the systematic analysis, the newly designed potential quinazolinone are suggested to be templates to design functionally improved inhibitors quinazolinone.

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