World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), Web of Science Group (Under Process), Directory of Research Journals Indexing, 

Abstract

ASSESSMENT OF ANTIDEPRESSANT EFFECT OF LEAVES FROM PAULLINIA PINNATA ON MICE

Bakou Niangoran François*, B. A. Abdoulaye, Guiro Hamidou and Atayi E.

ABSTRACT

Objective: The aim of the present study is to evaluate the antidepressant-like effect of hydro alcoholic extract of leaves from Paullinia pinnata in mice. Materials and Methods: Mice were randomly divided into five groups (n = 5/group): control group (distilled water), standard group where Amitriptyline (20mg/kg b.w., IP) was used as standard drug and three test groups where three doses of the hydro alcohol extract of PP (50, 100, and 200 mg/kg) was used for two weeks treatment. To assess the antidepressant-like effect of PP forced swimming test (FST), tail suspension test (TST) and measurement of locomotor activity test (OFT) have been done in mice. Results: The results showed that a strong and dose-dependent antidepressant effects in different mice models. The main findings of the ML significantly reduced the duration of immobility times in the forced swimming test (p < 0.001). Likewise, the extract significantly decreased the immobility time in the tail suspension test (p < 0.001). Conclusion: The results of the present work suggest that a hydro alcoholic extract of Paullinia pinnata leaves may possess an antidepressant effect.

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