World Journal of
Pharmaceutical and Life Sciences

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), Web of Science Group (Under Process), Directory of Research Journals Indexing, 



Danni Ramdhani* and Resmi Mustarichie


Objective: Investigation of the anticancer mechanism of apigenin bioflavonoid compounds was carried out through docking experiments with 3 different molecular targets; Vascular Endothelial Growth Factor R2 (VEGFR2), Procaspase 7, Protein Kinase B were known to be involved in the physiology of cancer. The interaction of apigenin was compared with the interaction of each original crystallized ligand at the active location of this receptor. This comparison was based on the parameters of their docking results, as well as, the type of interaction that occured with various amino acids on the active side of the bonding pocket. Materials and Methods: Molecular docking studies began by downloading the receptor file as a target on the Protein Data Bank (PDB), and the ligand structure was obtained from pubchem and zinc. docking. The preparation of receptors and ligands was done with discovery studio software, pyrx, MgTool, followed by docking and visualization processes using AutoDock Vina and Discovery Studio Visualizer. Results: The binding activity value as a docking score was obtained -7.6 kcal/mol for interaction with the procaspase 7 receptor, protein kinase B receptor B -9.1 kcal/mol, and VEGFR2 -7.3 kcal/mol. Conclusions: Molecular docking studies showed that the flavonoid apigenin compound had the strongest affinity and potential as an anticancer through the inhibition mechanism of protein kinase B receptors.

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