World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

FORMULATION AND EVALUTION OF MUCOADHESIVE BUCCAL FILMS OF MOSAPRIDE CITRATE

*Likhith H. S., Suresh V. Kulkarani*, K. Manjunath, Pawan C., Arjun K. L.

ABSTRACT

Gastro-prokinetic medications are pharmacological agents that are used to treat Gastro-esophageal reflux disease. The aim of the present study is to formulate and evaluate mucoadhesive buccal film of Mosapride citrate. Mosapride buccal films were prepared by using different polymers like HPMC K100, HEC, HPC and Glycerol as plasticizer and saccharin as a sweetening agent and vanillin as a flavoring agent. Buccal films were prepared using solvent casting technique. The major problem with Mosapride was it belongs to class ? in BCS classification and have low solubility in biological fluids. In order to enhance the solubility of mosapride solid dispersion of mosapride were prepared by melting technique at different drug carrier (PEG 4000) weight ratios and evaluated. No interaction was found between the drug and the polymers by the FTIR studies. The buccal films were evaluated for Folding endurance, weight variation, Drug content, Thickness, permeation study and in-vitro drug release study Dissolution profile as studied in USP dissolution apparatus type 1 using pH 6.8simulated saliva. The influence of variable like polymer type, concentration, of Mosapride citrate release profile was studied. The formulation was optimized on the basis of various evaluation parameters like drug content and In-vitro drug release. Formulation F3 successfully sustained the release of drug within 7 hours. stability studies were as per ICH guide lines and result indicated that the selected formulation was stable.

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