World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
World Journal of Pharmaceutical and Life Sciences (WJPLS) has indexed with various reputed international bodies like : Google Scholar, Index Copernicus, Indian Science Publications, SOCOLAR, China, Cosmos Impact Factor, Research Bible, Fuchu, Tokyo. JAPAN, Scientific Indexing Services (SIS), Jour Informatics (Under Process), UDLedge Science Citation Index, Global Impact Factor (In Process), International Impact Factor Services, International Scientific Indexing, UAE, International Society for Research Activity (ISRA) Journal Impact Factor (JIF), Science Library Index, Dubai, United Arab Emirates, International Innovative Journal Impact Factor (IIJIF), Scientific Journal Impact Factor (SJIF), Eurasian Scientific Journal Index (ESJI), Indian citation Index (ICI), IFSIJ Measure of Journal Quality, International Scientific Indexing, UAE (ISI), Web of Science Group (Under Process), Directory of Research Journals Indexing, 

Abstract

MULTIDRUG RESISTANT (MDR) UROPATHOGENS PROFILE IN HIV-POSITIVE INDIVIDUALS WITH ASYMPTOMATIC BACTERIURIA IN PORT-HARCOURT, NIGERIA

Obi-Thomas Jane Nkechi*, Frank-Peterside Nnenna and Agbagwa Obakpororo Ejiro

ABSTRACT

Asymptomatic bacteriuria (ASB) refers to the quantitative growth of same species of bacteria in mid-stream urine to the tune of 105 CFU/ml or above with no presence of any signs and symptoms of urinary tract infections. Asymptomatic bacteriuria is a common occurrence in healthy individuals with HIV sero-positive individuals at greater risk. The study aimed to determine the prevalence of asymptomatic bacteriuria and the sensitivity patterns of the isolates among HIV-positive individuals assessing medical care in Port-Harcourt. Early morning urine samples were collected from HIV positive persons attending University of Port-Harcourt Teaching Hospital (UPTH) and analyzed using standard procedures. Statistical analysis was carried out using SPSS version 20.0 (USA). Of the four hundred (400) urine samples, asymptomatic bacteriuria was diagnosed in 203 (50.75%). Escherichia coli, 50 (24.63%) were the highest uropathogens isolated followed by Klebsiella species 42 (20.96%), Pseudomonas species 34 (16.75%), Enterobacter species 26 (12.81%), Proteus species 22 (10.84%), Providencia species 16 (7.88%), Staphylococcus aureus 5 (2.46%), Alcaligenes species 2 (0.99%), Enterococcus species 2 (0.99%) and Candida albicans 4 (1.97%) in that order. Antibiotic susceptibility patterns showed 66% and above resistance rates by all the isolates except Staphylococcus aureus which had 49% resistivity to all the 7 classes of antibiotics used. Alcaligenes species and Enterococcus species were 100% resistant to the antibiotics. In this study, Escherichia coli was the most prevalent organism. Multiple antibiotic resistance is high among sero-positive individuals attending UPTH in Port-Harcourt. Regulation of antibiotic use is lacking in Nigeria and Government needs to tackle it.

[Full Text Article]

BEST PAPER AWARDS

World Journal of Pharmaceutical and life sciences Will give best paper award in every issue in the from of money along with certificate to promote research .

Best Article of current issue

Download Article : Click here